The significance and application of iPSCs

Stem cellsIt has become an indispensable source of cells in the rapidly developing fields of regenerative medicine and drug development. Induced pluripotent stem cells (iPSCs) are terminally differentiated somatic cells that can differentiate into multiple cell types.IPSCs differentiated cells can reproduce the cellular pathology of patients with gene mutations,Therefore, iPSCs have broad application prospects in fields such as disease modeling and the development of new treatment methods.

The main problem of failure in the clinical trial stage of drug development and subsequent new drug application/biopharmaceutical license application stage is the lack of clinical effectiveness（48%）And safety（31%）。In preclinical basic research, animal testing is the main method for in vivo drug testing. The differences and limited scalability between animal models and humans make it difficult to develop and rely on preclinical biomarkers to accurately predict the efficacy and toxicity of drug development in clinical stages. IPSCs have promoted our understanding of the molecular mechanisms of human diseases, drug discovery, and regenerative medicine, and their use in drug development and validation has shown a rapid growth trend.

In addition，IPSCs have the ability to reproduce donor phenotypes，Human iPSCs derivatives can be used to identify highly relevant biomarkers throughout the entire drug discovery and development process to link preclinical and in vitro toxicity testing. Many laboratories have successfully replicated many disease phenotypes that are often difficult or impossible to capture in commonly used cell lines or animal models.